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科学领域:

  • 神经免疫学 神经免疫学
  • 儿科神经学 儿科神经学
  • 神经成像是一种神经成像.

背景情况:

  • 冠状动脉 (CP) 与多发性硬化症 (MS) 中的中枢神经系统 (CNS) 炎症有关.
  • 儿科发作的MS (POMS) 呈现出显著的炎症活性,使其成为研究早期炎症变化的相关模型.

研究的目的:

  • 为了比较患有POMS的儿童与健康的对照人群 (HCs) 的状体体积 (CPV).
  • 评估POMS的第一年CPV的变化.
  • 在POMS中调查CPV,大脑体积,疾病活动和残疾之间的关联.

主要方法:

  • 分析了23名POMS参与者和23名HC的1.5T MRI扫描,其中18名POMS参与者进行了12个月的随访扫描.
  • 使用手动细分来确定CPV,并将其正常化为内体积.
  • 研究人员检查了CPV和脑/损伤体积,复发率以及扩展残疾状况量表 (EDSS) 分数之间的相关性.

主要成果:

  • 与HC相比,POMS参与者 (1.51 × 10−3) 的正常化CPV显著增加 (1.21 × 10−3;p=0.001).
  • 在POMS参与者中,CPV在第一年没有显著变化 (p=0.352).
  • CPV与侧腔室体积相关,但与大脑体积,T2病变,复发活动或EDSS分数无关.

结论:

  • 与HC相比,POMS患儿的基线CPV在儿童中升高.
  • 基线CPV升高似乎不能预测POMS第一年内的疾病活性或神经结果.
  • 虽然增加的CPV可能表明MS的早期炎症,但其与心室体积的相关性需要进一步调查.