生命的基本8和中年成年人中糟糕的大脑健康结果
Santiago Clocchiatti-Tuozzo1, Cyprien A Rivier1, Daniela Renedo1
1From the Department of Neurology (S.C.-T., C.A.R., D.R., S.H., A.H., L.H.S., K.N.S., G.J.F.); Yale Center for Brain and Mind Health (S.C.-T., C.A.R., D.R., S.H., A.H., K.N.S., G.J.F.); Department of Internal Medicine (S.C.-T., T.M.G.), Geriatrics, Yale School of Medicine, New Haven, CT; and Department of Neurology (M.A.H.), Mayo Clinic, Rochester, MN.
Neurology
|October 23, 2024
概括
中年时心血管健康不佳显著增加了中风,痴呆和晚年抑郁症的风险. 优化美国心脏协会的生命必需8 (LE8) 指标可以改善长期的大脑健康.
科学领域:
- 心血管健康和神经病学
- 公共卫生和流行病学
- 老年学和衰老研究研究.
背景情况:
- 越来越多的证据将中年心血管风险与晚年大脑健康联系在一起.
- 美国心脏协会的生命必需品8 (LE8) 衡量心血管健康.
- 关于LE8对大脑健康结果的影响仍在调查中.
研究的目的:
- 测试较差的LE8概况是否与主要大脑健康终点风险增加有关.
- 评估心血管健康指标与复合脑健康结果之间的关联.
主要方法:
- 使用英国生物银行和我们所有人的数据集进行两阶段前性研究.
- LE8评分评估了心血管风险因素 (血压,葡萄糖,胆固醇,BMI,吸烟,活动,饮食,睡眠).
- 综合结局包括中风,痴呆症或晚年抑郁症,使用考克斯比例危险模型进行分析.
主要成果:
- 在英国生物库 (n=316,127) 中,低LE8与复合结局风险增加2.11倍有关 (HR 2.11,95% CI 1.88-2.36).
- 在我们所有人 (n=68,407) 中,贫困的LE8与1.94倍更高的风险相关 (HR 1.94,95% CI 1.72-2.18).
- 在发现和复制队伍中存在着显著的关联 (p趋势<0.001).
结论:
- 较差的心血管健康状况,以LE8衡量,与主要脑健康疾病的风险增加一倍有关.
- 这些发现强调了优化LE8对大脑健康的重要性.
- 可修改的心血管风险因素为预防认知衰退和相关疾病提供了目标.
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