在患有多发性硬化症的患者中,采用干细胞疗法进行多次治疗的效果
Liding Fan1, Yunfei Zhang2, Shuo Huang3
1Jining Medical University, Second Clinical Medical College, Shandong, 272067, China.
Multiple sclerosis and related disorders
|October 23, 2024
概括
干细胞疗法,如自身造血干细胞移植 (AHSCT) 和介质干细胞 (MSCs),在治疗多发性硬化症 (MS) 方面表现有前途. 人类带衍生MSC有效降低MS患者的复发率和残疾.
科学领域:
- 再生医学是一种再生医学.
- 神经免疫学 神经免疫学
- 临床试验 临床试验
背景情况:
- 多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
- 目前的多发性硬化症治疗旨在控制症状并减缓疾病的进展,但需要新的治疗策略.
- 干细胞疗法在MS中具有神经保护和免疫调节的潜力.
研究的目的:
- 评估干细胞疗法,特别是自身造血干细胞移植 (AHSCT) 和介质干细胞 (MSC) 的比较有效性,与多发性硬化症的非干细胞疗法相比.
- 综合来自临床试验的证据,研究各种干细胞干预措施对多发性硬化症活动和患者结果的影响.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆进行了系统的文献搜索,寻找相关的临床试验.
- 考克兰偏差风险评估工具被用于研究质量评估.
- 进行了数据分析,以评估不同干细胞疗法的疗效.
主要成果:
- 纳入了10项涉及5288名参与者的研究. 人类带衍生中干细胞 (hUC-MSCs) 显著降低了MS患者的年复发率 (ARR) 和扩展残疾状态量表 (EDSS).
- 自主造血干细胞移植 (AHSCT) 证明了死亡率的降低.
- 自主外周血液干细胞移植 (APBSCT) 在减少疾病复发和改善无疾病活动证据-3 (NEDA-3) 状态方面有效.
结论:
- AHSCT和MSCs,特别是hUC-MSCs,在减少MS复发和改善残疾方面表现出有效性.
- 虽然APBSCT和AHSCT在某些方面显示出好处,但它们关于NEDA-3标准的结果需要进一步调查.
- 干细胞疗法是治疗多发性硬化症的一个有希望的途径,特定类型具有明显的优势.
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