估计由于未知暴露时间而导致的乙胺摄入量的不确定性
Minal Y Nadar1, S Halder1, L Mishra1
1Radiation Safety Systems Division, Bhabha Atomic Research Centre, Mumbai, 400085, India.
概括
由于未知的摄入时间,估计处理活性化物的工人的内部辐射暴露是具有挑战性的. 年度肺部监测为某些化合物提供了最准确的评估,而尿液分析为其他化合物提供了可靠的数据.
科学领域:
- 职业健康 职业健康 职业健康
- 辐射保护 辐射保护
- 辐射监测 辐射监测
背景情况:
- 每年对照射工人处理活性化物进行常规生物测试.
- 估计摄入量是不确定的,因为暴露的确切日期是未知的,通常被认为是监测间隔的中点.
- 这种假设在内部剂量评估中引发了重大不确定性.
研究的目的:
- 评估M型和S型 (Pu) 和 (U) 化合物的摄入量估计中的不确定性.
- 为了评估这些不确定性,对每年和每两年监测间隔进行评估.
- 为了比较不同的监测方法,包括肺部和排泄物分析,考虑到测量变化.
主要方法:
- 对和U的M型和S型化合物进行了不确定性分析.
- 考虑的监测间隔是每年和每两年一次.
- 评估了肺部和排泄物监测方法,包括±1或±2个月的测量差.
主要成果:
- 年度肺部监测是S型化合物Pu,Americium (Am) 和U的最稳健的方法,当摄入时间不清楚时.
- 尿液分析显示,S型Pu和U化合物和M型Pu化合物的不确定性在两段时间内都低于3.
- 便分析表明,在两次监测间隔内,M型和S型Pu和U化合物的不确定性都大于3.
结论:
- 年度肺部监测提供了准确的评估特定的化物暴露,当摄入时间是不确定的.
- 在常规监测下,尿液生物测试对某些活性化物化合物 (类型S Pu/U,类型M Pu) 是可靠的.
- 便分析显示,和摄入量估计的不确定性更高,特别是在M型化合物中.
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