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发现蓝光胺衍生物作为偏向的μ-阿片类受体激活剂

Liang-Han Zhu1, Hui-Huan Mao1, Mingchao He2

  • 1State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.

Bioorganic & medicinal chemistry
|October 23, 2024
PubMed
概括

研究人员通过修改PZM21开发了一种新的偏向型片受体 (MOR) 激动剂,化合物I-11,通过修改PZM21. 这种化合物提供了与吗啡相似的强效止痛药,但通过选择性地激活MOR而避免常见的副作用,而无需β-arrestin2通路.

关键词:
2-Cyanoguanidine 脚手架的架构是可以使用的.止痛药是一种止痛药.有偏差的μ-阿片类受体激活剂.这就是β-Arrestin2的作用.

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