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2024年血液中组织因子检测的最新情况:叙述性审查

Amandine Bonifay^1,2, Sylvie Cointe^1,2, Léa Plantureux¹

¹Aix-Marseille University, C2VN, INSERM 1263, INRAE 1260, Marseille, France.

Hamostaseologie

|October 23, 2024

概括

组织因子 (TF) 测定测量其在血液凝固和血栓形成中的作用. 细胞外膀TF (EVTF) 的功能测试显示出希望,但需要为临床使用标准化.

科学领域:

生物化学生化学
血液学血液学血液学
血栓形成研究研究

背景情况:

组织因子 (TF) 是血液静止和血栓形成的关键蛋白质.
循环TF存在于各种形式,包括在细胞外囊泡 (EVs) 中.
TF在血栓形成中的作用需要可靠的测量方法.

研究的目的:

审查和比较测试以测量循环TF抗原和活性.
讨论影响TF测定结果的预分析和分析因素.
突出了EVTF分析的发展和挑战.

主要方法:

出版的TF和EVTF试验的文献综述.
分析试验性能,包括特异性和灵敏性.
讨论影响TF测量的预分析和分析参数.

主要成果:

对于TF和EVTF存在许多测定方法,具有不同的临床实用性.
功能性EVTF测定显示出比抗原测定更高的特异性和灵敏性.
不同的EVTF测定之间仍然存在显著的变化.

结论:

TF测定对于预测各种疾病中血栓形成风险非常有价值.
功能性EVTF测定提供了更好的诊断潜力.
标准化和自动化对于EVTF试验的临床实施至关重要.

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