虚拟抗原受体T细胞治疗在风湿病中的结果:系统性审查
Fizza Zulfiqar1, Moazzam Shahzad2, Muhammad Kashif Amin1
1Division of Hematologic Malignancies & Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States; Mikael Rayaan Foundation Global Transplantation and Cellular Therapy Consortium, Kansas City, Kansas, United States.
Transplant immunology
|October 23, 2024
概括
化学抗原受体 (CAR-T) 疗法对风湿病具有前景,大多数患者出现症状改善和疾病标志物减少. 需要进一步的试验来确认长期的安全性和有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 类风湿病学 类风湿病学
背景情况:
- 化学抗原受体T细胞 (CAR-T) 疗法是一种新型免疫疗法,已在治疗血液性恶性瘤方面取得成功.
- 它的有效性激发了人们对应用CAR-T疗法的兴趣,用于耐火性类风湿性疾病.
研究的目的:
- 审查CAR-T细胞治疗在患有类风湿病的患者当前的使用和结果.
- 分析现有关于CAR-T治疗自身免疫和风湿病的研究中的人口统计和临床数据.
主要方法:
- 在PubMed,Cochrane和ClinicalTrials.gov.gov网站上按照PRISMA指南进行了系统的文献搜索.
- 关键词包括"CAR-T细胞疗法"和"风湿病";2977篇文章被选,产生了六项相关研究进行分析.
- 对101名成年患者的病例报告,病例系列,观察性研究和两项临床试验数据进行了描述性分析.
主要成果:
- 该审查包括101名成年患者 (平均年龄为50.8岁),患有类风湿性关节炎和全身性红斑狼等疾病.
- CAR-T疗法向CD-19或BCMA;六项研究中的五项报告了100%的响应率.
- 在大多数研究中,不良事件包括1-2级细胞因子释放综合征 (CRS),其中有一例是3级以上的CRS,神经毒性率低.
结论:
- 卡特-T细胞疗法在治疗类风湿性疾病方面取得了重大进展,提供了症状缓解和生化控制.
- 初步发现令人鼓舞,但长期跟踪和前性试验对于确定最佳使用,安全性和有效性至关重要.
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