对植入综合征的机构洞察:关于异构移植结果的队列研究
Júlia Plentz Portich1, Aline Sinhorelo Ribeiro1, Lisandra Della Costa Rigoni1
1Bone Marrow Transplantation Department from Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Transplant immunology
|October 23, 2024
概括
血造干细胞移植 (HSCT) 后的移植综合征 (ES) 发生在16.5%的成人和28.6%的儿童中. ES与更长的住院时间和抗生素对耐药细菌的使用有关.
科学领域:
- 血液学 血液学 血液学
- 移植免疫学 移植免疫学
- 临床医学 临床医学
背景情况:
- 移植综合征 (ES) 是血造造干细胞移植 (HSCT) 后的一种并发症.
- 由于各种标准及其与移植与宿主疾病 (GVHD) 的不清楚关系,ES诊断是复杂的.
研究的目的:
- 为了确定ES的发生率.
- 探索ES和GVHD在异性HSCT患者之间的关系.
主要方法:
- 从2015年至2016年对异性HSCT (alloHSCT) 患者进行的回顾性队列研究.
- 使用斯皮策或迈奥利诺标准进行ES诊断.
主要成果:
- 在ES的发病率为16.5% (成年人) 和28.6% (儿童).
- ES与长时间住院相关 (14天以上).
- 对多药耐药细菌的抗生素使用与ES发展有积极的相关性.
结论:
- 这一群人中的ES发病率与现有文献一致.
- ES与显著更长的住院时间有关.
- 对抗多药耐药细菌的宽谱抗生素的预防性或治疗性使用可能会增加ES的风险.
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