收入差异对甲状腺癌复发和生存率有重大影响
Mohammad H Hussein1, Julia A McGee2, Luu Alexandria2
1Department of Surgery, School of Medicine, Tulane University, New Orleans, LA 70112, USA; Ochsner Clinic Foundation, New Orleans, LA 70112, USA.
Journal of cancer policy
|October 23, 2024
概括
更高的收入与更好的甲状腺癌结局有关,其复发率较低,生存率提高. 解决收入差距对于促进癌症护理中的健康公平至关重要.
科学领域:
- 在瘤学瘤学.
- 健康 公平 卫生 公平
- 健康的社会经济决定因素
背景情况:
- 收入不平等在不同类型的癌症中显著影响癌症的结果.
- 社会经济差异对甲状腺癌预后的具体影响尚未明确.
- 了解这些差异对于改善患者护理和实现健康公平至关重要.
研究的目的:
- 评估家庭收入中位数与甲状腺癌复发之间的关联.
- 评估家庭收入中位数与甲状腺癌存活率之间的关系.
- 通过使用国家数据,阐明社会经济因素在甲状腺癌结果中的作用.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 数据库 (2000-2019) 中对139,302名甲状腺癌患者的分析.
- 患者按县级家庭年收入中位数 (>75000美元与<75000美元) 分层.
- 使用多变量回归模型来确定收入对复发和死亡率的影响.
主要成果:
- 收入较高的患者出现复发的几率降低了26% (OR 0.74,p=0.042).
- 收入较高的患者的中位生存时间更长 (18.1年与17.7年,p<0.001).
- 在调整后,高收入独立预测降低死亡率 (aHR=0.84,p<0.001);手术和放射性也降低了死亡风险.
结论:
- 显著的收入差异影响甲状腺癌复发率和死亡率.
- 解决社会经济不平等问题可以大大减少复发并提高生存率.
- 针对收入差距对于促进甲状腺癌患者护理中的健康公平至关重要.
相关概念视频
01:21Cancer Survival Analysis
328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
01:20Synthesis and Regulation of Thyroid Hormones
4.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.2K
01:18Functions of Thyroid Hormones
2.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.6K
01:20Comparing the Survival Analysis of Two or More Groups
155
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
155
01:27Tumor Immunotherapy
486
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
486
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K