在患有情感和焦虑谱系障碍的患者中,跨诊断性白质可控性缺陷
Biqiu Tang1, Hengyi Cao2, Shikuang Deng3
1Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Journal of affective disorders
|October 23, 2024
概括
大脑网络可控性在严重抑郁症 (MDD),创伤后应激障碍 (PTSD) 和社会焦虑障碍 (SAD) 中发生变化. 这些情绪和焦虑障碍显示大脑网络控制的减少,影响功能动态.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 网络科学 网络科学
背景情况:
- 情绪和焦虑障碍,如严重抑郁症 (MDD),创伤后应激障碍 (PTSD) 和社会焦虑障碍 (SAD) 与大脑网络失联有关.
- 网络可控性衡量大脑区域根据结构连接影响功能动态的能力.
研究的目的:
- 调查MDD,PTSD和SAD网络可控性的共享和独特的变化.
- 探索网络可控性与疾病特征之间的关系.
主要方法:
- 在233名个人中比较白质网络可控性 (68名MDD,51名PTSD,46名SAD,68名健康对照).
- 评估了可控性,症状严重程度和未经治疗的疾病持续时间之间的关联.
主要成果:
- 与对照人群相比,患有PTSD,MDD和SAD的患者在体运动,皮质下和默认模式网络中平均可控性降低.
- 某些特定区域,如上侧额,中后和皮,表现出控制能力下降.
- 患有MDD和SAD的患者在左侧尾和腰部的可控性降低;SAD患者还显示背部注意力网络的减少.
- 在可控性变化与疾病持续时间或症状严重程度之间没有发现显著的相关性.
结论:
- 揭示了MDD,PTSD和SAD中常见和独特的网络可控性改变.
- 表明特定大脑区域/网络在这些疾病中驱动功能状态的能力下降.
- 突出了理解和治疗这些疾病的潜在跨诊断目标.
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