相关实验视频
Updated: Jun 9, 2025

09:26
Synthesis and Characterization of Supramolecular Colloids
Published on: April 22, 2016
9.7K
超分子合成的潜力,以开发具有量身定制的物理稳定性的共同形态系统:整合动力学和热力学的机械洞察力
Yutong Song1, Yu Chen2, Weili Heng3
1School of Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China; School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
International journal of pharmaceutics
|October 23, 2024
概括
设计稳定的同形药物递送系统对于溶性较差的药物至关重要. 这项研究使用了超分子合成方法来创建卢拉西化同形系统,揭示了影响其物理稳定性的关键因素.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 同形药物递送系统提高了水溶性较差的药物的溶性和生物可用性.
- 物理稳定性,特别是结晶风险,仍然是同形配方的主要挑战.
- 传统上,识别最佳协同形成者依赖于耗时且昂贵的试错方法.
研究的目的:
- 使用超分子合成方法设计和评估与糖 (SAC),L-酸 (TRP) 和L-氨酸 (CYS) 结合的卢拉西化 (LH) 的共同形态系统 (CM).
- 研究分子间相互作用和功能组在确定这些同形系统的物理稳定性方面的作用.
- 阐明超分子合成子,分子流动性,配置和同形配方的整体物理稳定性之间的关系.
主要方法:
- 使用卢拉西化和三种不同的共同成型剂制备了共形系统.
- 使用X射线粉末衍射来评估物理稳定性.
- 通过红外光谱学和固态13CNMR确认了分子间相互作用.
- 理论计算,包括混合性,分子动力学和量子化学计算,用于量化结构和相互作用参数.
主要成果:
- 同形系统的物理稳定性被排列为:LH-CYS CM > LH-TRP CM > LH-SAC CM.
- 电荷辅助的键被证实,LH-CYS CM表现出最强的结合能和部分共价性质的键.
- 虽然LH-CYS CM显示出优越的可混合性和相互作用,但LH-TRP CM显示出最低的分子流动性;然而,配置与所有系统的物理稳定性直接相关.
结论:
- 超分子合成方法通过定制分子间相互作用,有效地稳定了共形配方.
- 动力 (分子运动) 和热力学 (配置) 因素都影响物理稳定性,配置和分子间相互作用之间存在强烈的相关性.
- 这项研究为设计具有可预测和增强物理稳定性的共形系统提供了更深入的机械学理解.
相关概念视频
Cycloaddition Reactions: MO Requirements for Thermal Activation
3.5K
Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
3.5K
Stability of Substituted Cyclohexanes
12.4K
This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
12.4K
Polymer Classification: Crystallinity
2.8K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
2.8K
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
288
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
288
Polymer Classification: Stereospecificity
2.4K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
2.4K
Complexation Equilibria: Factors Influencing Stability of Complexes
345
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
345

