在患有口腔平的患者中,受损的唾液微生物群是性别特异的
Shiping Lv1, Li Yan2, Yunmei Dong1
1College of Stomatology, Chongqing Medical University, Chongqing, 401147, China; Chongqing Key Laboratory of Oral Diseases, Chongqing, 401147, China.
Microbial pathogenesis
|October 23, 2024
概括
口腔平坦 (OLP) 在性别之间显示出明显的唾液微生物群差异. 这项研究确定了特定的细菌生物标志物和代谢途径,表明男性和女性OLP患者的独特致病性.
科学领域:
- 微生物学 微生物学
- 口腔医学是指口腔医学.
- 基因组学就是基因组学.
背景情况:
- 口腔平坦 (OLP) 是一种具有不明原因的炎症状况.
- 了解性别特异性因素可以阐明OLP的病原性.
研究的目的:
- 为了研究口腔平 (OLP) 中的特定性别的唾液微生物组概况.
- 为了确定潜在的特定性别的唾液微生物组生物标志物用于OLP诊断.
主要方法:
- 从男性和女性OLP患者和健康对照人群收集唾液样本.
- 使用16S rRNA基因测序来分析唾液微生物组合.
- 进行基于性别的比较以确定差异.
主要成果:
- 在OLP患者和对照人群之间观察到唾液微生物组合的显著差异,特别是在女性中.
- 在女性OLP患者中观察到伪菌的丰富.
- Rhodococcus和Pseudomonas分别显示出作为男性和女性OLP的诊断生物标志物的潜力.
- 代谢功能障碍和特定的微生物途径在女性患者中更为明显.
- 特定细菌 (Capnocytophaga,Neisseria,Rothia) 和临床参数 (侵蚀区域,疼痛) 之间的相关性被以特定性别的方式确定.
结论:
- 该研究强调了OLP患者的唾液微生物组的性别特异性变化.
- 这些发现表明,男性和女性OLP患者可能表现出不同的致病机制.
更多相关视频
08:37Sampling Human Indigenous Saliva Peptidome Using a Lollipop-Like Ultrafiltration Probe: Simplify and Enhance Peptide Detection for Clinical Mass Spectrometry
Published on: August 7, 2012
11.4K
10:42Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
17.1K
相关概念视频
Salivary Glands and Saliva
494
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
494
What is Monogastric Digestion?
70.7K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.7K
