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自凝,可调整的粘附,抗菌和生物相容的四重化纤维素/酸/聚乙烯甘醇/蒙莫里隆尼特复合粉末用于快速静血

Xuanyu Liu¹, Yinchun Hu¹, Junjie Hu¹

¹Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China.

International journal of biological macromolecules

|October 23, 2024

概括

一种新的自凝血静止粉末 (QTPM) 提供快速,有效的出血控制和感染预防. 这种先进的生物材料显示出与临床使用的传统粉末相比显著的改进.

科学领域:

生物材料科学生物材料科学
血液静止研究血液静止研究
伤口管理伤口管理

背景情况:

传统的静血粉缺乏粘附性,有效的静血和感染控制.
现有的治疗方法往往不适合复杂的伤口和紧急情况.

研究的目的:

开发一种具有增强性能的新型自凝血静止粉末 (QTPM).
评估QTPM的静血和抗菌疗效.
评估QTPM作为临床生物材料的潜力.

主要方法:

QTPM是使用四元化纤维素 (QC),酸 (TA),聚乙烯糖醇 (PEG) 和蒙莫里隆石 (MMT) 合成的.
该粉末被测试了其形成水凝和粘附于组织的能力.
通过QC和TA的协同作用来评估抗菌性质.
在体内研究中,利用肝脏出血和尾部截肢模型来评估血液静止.

主要成果:

在水化后,QTPM形成一个稳定的水凝,具有可切换的组织粘附.
粉末显示出显著的抗菌活性.
QTPM加速了血液静止,并分别减少了超过75%和85%的血液损失.
肝脏出血模型的具体结果:71.67 ± 7.09秒的静血时间,19.23 ± 2.60毫克的血液损失.
尾部截肢模型的具体结果:91.03±12.05秒的静血时间,15.24±1.77毫克的血液损失.

结论:

通过内在和外在通路激活,QTPM表现出快速有效的血液静止.
它的抗菌特性和水凝形成增强了它的效用.
QTPM的易于使用,储存和适应性使其成为临床血液静止的有希望的生物材料.

关键词:

抗微生物药物抗微生物药物纤维素是纤维素的一种.快速的血液静止迅速的血液静止自行凝的自我凝.潮湿的粘合力潮湿的粘合力

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