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通过昼夜节律调节来治疗阿基里斯肌病

Yibo Zhang¹, Yizhang Wu², Yong Wang³

¹State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.

Journal of advanced research

|October 23, 2024

概括

阿基里斯肌有一个昼夜时钟,在肌病中受到干扰,增加了氧化应激. 通过生物材料调节这个时钟,为阿基里斯肌病症提供了一个有前途的新疗法.

科学领域:

生物医学工程生物医学工程
时间生物学时间生物学
肌肉骨研究研究

背景情况:

阿基里斯肌病 (AT) 是一种与氧化应激相关的常见疾病.
昼夜时钟节律可能会影响氧化应激,但它们在AT中的作用尚未完全理解.

研究的目的:

研究阿基里斯肌的昼夜时钟在AT病理中的作用.
探索生物材料来调节昼夜时钟以治疗AT.

主要方法:

用于体内和体外模型来研究AT的阿基里斯肌时钟变化.
制造的Nb2C@CeO2复合材料具有Schottky异质连接来调节昼夜节律.
在AT模型中验证了治疗疗效和分子机制.

主要成果:

阿基里斯肌充当外周振荡器;它的时钟节奏在AT中被破坏,减少Bmal1和Nrf2的表达.
通过损害Bmal1-Nrf2防御轴并增加炎症,Bmal1的敲击会加剧AT.
Nb2C@CeO2复合物改善了细胞间的电信号传输,增强了Bmal1,并减轻了AT病理.

结论:

昼夜时钟保护阿基里斯肌免受氧化应激和炎症的影响.
准阿基勒斯肌的昼夜时钟是AT的潜在治疗策略.

关键词:

阿基里斯肌病变 - - 阿基里斯肌病变在Bmal1-Nrf2轴上循环节的时钟是循环节的时间.斯科特基异质连接的异质连接给药时间给药时间

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