甲状腺眼病产后诊断的发生率与甲状腺功能的关系在Graves病中
Nami Suzuki1, Jaeduk Yoshimura Noh1, Ai Kozaki2
1Department of Internal Medicine, Ito Hospital, Tokyo 150-8308, Japan.
Endocrine journal
|October 23, 2024
概括
产后甲状腺眼病 (TED) 在0.65%的格雷夫斯病患者中发生. 甲状腺功能障碍在TED诊断之前超过一半,在新诊断的格雷夫斯病中,TRAb水平更高.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 生殖医学 生殖医学
背景情况:
- 格雷夫斯病 (GD) 可以在怀孕期间和产后波动.
- 产后甲状腺功能障碍的恶化或复发是可能的.
- 甲状腺眼病 (TED) 是GD的自身免疫并发症.
研究的目的:
- 为了确定产后TED诊断的发生率.
- 探索产后TED与甲状腺功能障碍之间的关系.
- 分析与TED开发有关的甲状腺功能和抗体水平.
主要方法:
- 追溯的横截面研究.
- 包括11,104例来自GD患者的分娩 (2004年1月至2022年8月).
- 分析了分娩后12个月内TED诊断和相关的甲状腺功能测试.
主要成果:
- 72名患者 (0.65%) 被诊断出患有TED产后.
- 甲状腺功能障碍在超过一半的病例中 (中位数为6.5个月与8.1个月) 先于TED.
- 与GD复发患者相比,新诊断的GD患者的TRAb水平显著更高.
结论:
- 产后TED诊断相对罕见,但与甲状腺功能障碍有关.
- 甲状腺功能障碍往往在分娩后期的TED诊断之前.
- 升高的TRAb水平可能表明新发性GD与产后TED的风险更高.
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