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在不丹连续两年 (2022年和2023年) 流感A ((H3N2) 病毒的演变

Tshering Dorji¹, Kunzang Dorji¹, Sonam Gyeltshen¹

¹National Influenza Centre (NIC), Royal Centre for Disease Control, Ministry of Health, Royal Government of Bhutan, Thimphu, Bhutan.

Influenza and other respiratory viruses

|October 23, 2024

概括

在不丹,流感A ((H3N2) 病毒主要是通过随机机会进化而不是通过适应. 持续监测对于管理这些不断变化的流感菌株的影响至关重要.

科学领域:

病毒学病毒学
流行病学流行病学
基因组学就是基因组学.

背景情况:

甲型流感病毒,特别是甲型H3N2病毒,由于其快速的遗传进化,造成了全球健康问题.
季节性流行病是由流感病毒的血凝素 (HA) 基因的变化驱动的.

研究的目的:

调查2022年至2023年期间在不丹传播的A(H3N2) 流感病毒的进化动态.
了解这些病毒在该地区的起源和传播模式.

主要方法:

通过GISAID获得的166个来自不丹的A(H3N2) 全基因组序列的分析.
贝叶斯马尔科夫链蒙特卡洛 (MCMC) 框架与全球HA序列数据的应用.
进行植物遗传学,时间和植物地理学分析.

主要成果:

鉴定了A(H3N2) 的流通3C.2a1b.2a.2类,其中有三个子类 (2a.3,2a.3a.1,2a.3b).
估计病毒血统起源于检测前大约1.93年.
植物地理分析表明,来自美国 (2022) 和澳大利亚 (2023) 的引入.
计算的平均进化速率为4.42 × 10-3个替代/地点/年,有纯化选择和有限的遗传多样性的证据.
观察到罕见的重组事件 (0.045事件/血统/年).

结论:

在不丹,A(H3N2) 的本地演变主要是随机的,适应性变化最小.
强调需要持续进行流感监测,以有效管理不断演变的病毒株.

关键词:

不丹是不丹的一个国家.在H3N2亚型.流感A型病毒感染者分子进化分子演变.突变是一种突变.

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