与代谢功能障碍相关的脂肪性肝病引起的抗氧化剂系统的变化:一篇综述
Gabriela Svobodová1, Martin Horní1, Eva Velecká1
1Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, 500 05, Hradec Králové, Czech Republic.
Archives of toxicology
|October 23, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 涉及氧化应激影响抗氧化酶. 早期的MASLD可以增强这些酶,但晚期的MASLD会减少活性,恶化肝损伤.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 生物化学 生物化学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 代谢功能障碍相关的脂肪酸性肝病 (MASLD) 是一种复杂的肝病,涉及脂肪酸,炎症,纤维化和肝硬化.
- 在MASLD中,慢性脂肪代谢中断与氧化应激有关,导致细胞损伤,如脂毒性和线粒体功能障碍.
研究的目的:
- 综合审查与MASLD相关的抗氧化酶表达和活性中的变化.
- 检查非酶性抗氧化剂谷氨在MASLD中的作用.
- 为了概述维生素E在MASLD进展期间对抗氧化酶的治疗作用.
主要方法:
- 对MASLD和抗氧化剂防御机制的临床和实验研究的文献综述.
- 对关键抗氧化酶的变化进行分析:超氧化脱酶,甲酶,谷甲过氧化酶,谷甲S转移酶,谷甲减少酶和NAD(P) H:氨酸氧化降低酶.
- 包括关于非酶性谷氨水平和维生素E作用的数据.
主要成果:
- 在早期的MASLD中,抗氧化酶表达/活性通常会增加,以对抗活性氧物种.
- 在先进的MASLD中,抗氧化酶表达/活性通常会下降,加剧肝脏和肝外细胞损伤.
- 虽然研究结果显示了一些不一致性,但抗氧化酶在MASLD病变发生过程中的关键作用是显而易见的.
结论:
- 抗氧化酶在MASLD的发展和进展中起着至关重要的作用.
- 抗氧化防御的失调,特别是在后期阶段,显著导致MASLD的严重程度.
- 需要进一步的研究来澄清不一致性,并探索针对抗氧化途径的治疗策略.
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