以色列多发性硬化症的患病率基于卫生保健组织数据库的验证
Maha Hurani1, Idit Lavi2, Sivan Bloch1,3
1Multiple Sclerosis and Neuroimmunology Center, Department of Neurology, Lady Davis Carmel Medical Center, 7 Mikhal St, Haifa, 3436212, Israel.
Scientific reports
|October 24, 2024
概括
以色列的多发性硬化症 (MS) 患病率正在增加,反映了全球趋势. 研究人员使用Clalit健康服务数据开发了一种经过验证的算法,以准确识别患有MS的人.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 医疗信息学 医疗信息学
背景情况:
- 以色列缺乏国家多发性硬化症 (MS) 注册,使得疾病的流行率未知.
- 克拉利特医疗服务 (CHS) 是以色列最大的医疗保健提供商,拥有广泛的电子医疗记录 (EMR).
研究的目的:
- 在CHS数据库中开发和验证用于识别MS患者 (PwMS) 的算法.
- 使用经过验证的算法,估计以色列MS的患病率.
主要方法:
- 在CHS数据库中创建了一个算法,使用ICD-9代码或MS特定的疾病修饰治疗 (DMT) 处方来识别PwMS.
- 算法的性能与专家神经病学家的诊断进行了验证,计算了正预测值 (PPV),灵敏度 (Sn) 和特异性 (Sp).
- 分析了患者的分层随机样本的EMR,以确定算法的准确性.
主要成果:
- 最佳病例定义 (ICD-9代码340或至少一个DMT处置) 实现了PPV的87%,Sn的92%,Sp的90%.
- 使用这个定义,在以色列,分别在2011年,2016年和2021年,每10万人口中,MS患病率估计为68,82和95.
- 这项研究表明,以色列MS患病率呈上升趋势.
结论:
- 开发的算法提供了使用CHS数据库识别以色列PwMS的可靠方法.
- 在以色列,MS的估计患病率正在增加,与国际观察一致.
- 这种方法可以为公共卫生策略和在以色列为MS护理的资源分配提供信息.
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