危重病儿童中BNP与全因死亡率之间的关联:一项队列研究
Zhen Zhang1, Yuna Li1, Chunfeng Yang1
1Department of PICU, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Pediatric research
|October 24, 2024
概括
高水平的B型尿素 (BNP) 与重症儿童的死亡率增加有关. 具体来说,超过10,170 pg/ml的BNP显著增加了儿科重症监护病房患者的死亡风险.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 生物标志物研究的研究.
- 临床结果分析分析临床结果分析
背景情况:
- 升高的B型天然尿素 (BNP) 与成人心脏病患者的不良结果有关.
- 关于BNP与儿科患者全因死亡率之间的关联的数据有限.
研究的目的:
- 调查BNP水平与重症儿童全因死亡率之间的关联.
- 探索BNP与儿科重症监护室 (PICU) 的死亡率之间的非线性相关性.
主要方法:
- 从儿科重症监护数据库 (2010-2018) 中对3220名患者 (28天至18岁) 的回顾性分析.
- 利用两部分和多变量后勤回归来评估BNP与死亡率的关联.
- 采用受限立方斜线模型来检查非线性关系.
主要成果:
- 总体死亡率为6.7%,在增加的BNP水平 (P < 0.001) 时,死亡率明显更高.
- 在BNP≥10,170ppg/ml的患者中,死亡率的调整后几率比为2.017 (P=0.0032).
- 证实了非线性关系,较高的log2 BNP与死亡风险增加有关 (OR 1.28,P < 0.001).
结论:
- 在儿科重症监护病房患者中,BNP水平与全因死亡率有显著的相关性.
- 一个BNP水平≥10,170 pg/ml表明死亡的风险明显更高.
- 在PICU中,BNP作为一种有价值的预后工具,用于心脏和非心脏疾病.
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