患有支气管肺功能障碍症的儿童的脏并发症
Samantha W Wallace1, Erica R Geers2, Jason Z Niehaus3
1Pediatric and Adolescent Comparative Effectiveness Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. samwwall@iu.edu.
Pediatric research
|October 24, 2024
概括
患有支气管肺功能障碍 (BPD) 的儿童患有急性损伤 (AKI) 和慢性病 (CKD) 的比例很高. 密切监测脏并发症对于这些儿童至关重要.
科学领域:
- 儿科脏病学 儿科脏病学
- 新生儿科学 新生儿科学
- 肺部病理学 肺部病理学
背景情况:
- 支气管肺功能障碍症 (BPD) 是婴儿的慢性肺部疾病.
- 患有BPD的儿童的结局尚未得到充分了解.
- 这项研究调查了BPD队列中的脏并发症.
研究的目的:
- 描述BPD儿童的短期和长期结局.
- 在这个人群中评估急性损伤 (AKI) 和慢性病 (CKD) 的患病率.
主要方法:
- 在2010年至2020年之间出生的BPD儿童的回顾性队列研究.
- 使用新生儿KDIGO标准进行评估AKI.
- 评估了长期结果,包括CKD (eGFR<90mL/min/1.73m2),白色素尿和高血压.
主要成果:
- 在797名儿童中,38.8%的儿童在NICU入院期间经历了AKI.
- 有长期数据的510名患者中,有32.0%的患者在2.2岁的中位年龄前患有CKD.
- 观察到异常的eGFR (31.7%),蛋白尿 (12.5%) 和高血压 (15.2%).
结论:
- 患有BPD的儿童表现出高频率的AKI和CKD.
- 在BPD患者的结局需要增加注意力和监测.
- 研究结果表明,BPD与儿童早期严重的脏并发症有关.
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