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孕产妇的失生症会导致后代长期的行为变化

Jacob Hudobenko¹, Claudia M Di Gesù², Patrick R Mooz^3,4

¹Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT, USA.

Molecular psychiatry

|October 24, 2024

概括

先进的母亲年龄 (35岁以上) 与怀孕风险和后代神经发育问题有关. 母亲肠道微生物组的变化有助于这些风险,影响胎儿的损失和后代的行为.

科学领域:

生殖生物学生殖生物学
微生物学微生物学
神经科学是一个神经科学.

背景情况:

先进的孕产妇年龄 (AMA),定义为35岁以上妇女的怀孕,增加了孕产妇和新生儿并发症的风险.
AMA与子女中流产,死胎和神经发育/神经精神疾病的增加率有关.
肠道微生物组成的与年龄相关的变化可以改变宿主代谢并增加炎症.

研究的目的:

研究母体微生物组对妊娠结果和后代行为的特定贡献.
为了确定将老年母亲的微生物组转移到年轻的母是否会影响怀孕和后代的发育.

主要方法:

在怀孕之前,年轻的雌性小鼠被来自老年雌性捐赠者的肠道微生物群殖民.
评估了怀孕结果,后代的肠道微生物组合,神经递质水平和行为表型.

主要成果:

在怀孕前与老化微生物群的殖民化显著增加了年轻母婴的胎儿损失.
后代从出生到中年表现出持续的肠道微生物组变化.
后代显示神经递质和代谢物水平发生变化,以及抑郁和焦虑类行为.

结论:

与年龄相关的母体肠道微生物组变化与后代行为和生理学的慢性改变有关.
在出生前针对微生物组的干预措施可能提供一种策略,以减轻后代神经精神疾病的风险.

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