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Updated: Jun 9, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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在心力衰竭中准免疫纤维细胞通信

Junedh M Amrute1, Xin Luo2, Vinay Penna1

  • 1Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.

Nature
|October 24, 2024
PubMed
概括

炎症通过促进特定的纤维细胞群驱动心脏纤维化. 向免疫细胞和纤维细胞中的介质素-1β (IL-1β) 信号减少纤维化和改善心脏功能.

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Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
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