一个连接整体受体节点和部运动的皮质下养电路
Christin Kosse1, Jessica Ivanov1, Zachary Knight2
1Laboratory of Molecular Genetics, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Nature
|October 24, 2024
概括
研究人员发现一个控制饮食行为的大脑电路. 这一途径涉及中腹下垂体 (VMH) 中的大脑衍生神经营养因子 (BDNF) 神经元,将内部线索与食行为联系起来,并影响食物摄入.
科学领域:
- 神经科学
- 行为神经科学
- 下垂体电路
背景情况:
- 了解营养行为的神经通路对于解决代谢障碍至关重要.
- 互感信号与养输出之间的联系尚不完全理解.
- 大脑衍生神经营养因子 (BDNF) 在神经元功能和可塑性中起作用.
研究的目的:
- 将特定的皮层电路连接互感输入到养行为.
- 研究腹中下丘脑 (VMH) 中BDNF表达神经元在调节食物消耗和部运动中的作用.
主要方法:
- 通过对VMHBDNF神经元和周脑三角区域 (pMe5) 的光遗传学操纵来研究神经通路.
- 监测与食物供应,消费和动物肥胖相关的神经元活动.
- 从弧形核 (Arc) 神经元 (AgRP和POMC) 到VMHBDNF的神经元进行了检查.
主要成果:
- 从VMHBDNF神经元到部运动中心的直接电路被确定,控制食.
- 抑制VMHBDNF神经元增加了食物摄入量,并诱导了对非食物物体的消费行为.
- 这个Arc → VMHBDNF → pMe5电路感知能量状态并调节养行为.
结论:
- VMHBDNF神经元是营养行为的关键调节者, 关闭运动序列.
- 这种新发现的电路集成内部的能量信号来调节消耗的行为.
- 这种途径的失调可能导致肥胖和饮食模式的改变.
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