COVID-19的严重程度和皮质类固醇治疗对特定抗体生产的影响很小
Takato Nakamoto1, Noriko Iwamoto2, Yusuke Oshiro3
1Disease Control and Prevention Center/Travel Clinic, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-Ku, Tokyo, 162-8655, Japan. tnakamoto@hosp.ncgm.go.jp.
对COVID-19的甲治疗没有显著影响长期IgG抗体水平. 发病后一周的IgM水平可以预测疾病的严重程度和需要氧气.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 德克萨米他用于治疗2019年新冠病毒病 (COVID-19).
- 人们对其对特定抗体产生影响存在担忧.
- 这项研究调查了COVID-19严重程度和皮质类固醇治疗对抗体水平的影响.
研究的目的:
- 评估COVID-19严重程度对特定抗体生产的影响.
- 评估皮质类固醇治疗对COVID-19患者抗体水平的影响.
主要方法:
- 来自75名COVID-19患者的253个血清样本的回顾性分析.
- 测量严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 特定免疫球蛋白G (IgG) 和免疫球蛋白M (IgM) 抗体.
- 基于COVID-19严重程度和皮质类固醇使用的抗体水平的比较.
主要成果:
- IgM阳性在早期增加,而IgG阳性在16天后保持不变,无论疾病的严重程度如何.
- 在6-10天的中度COVID-19病例中观察到较高的IgG和IgM阳性率.
- 在中度病例中,IgG阳性保持不变,不论是用皮质类固醇.
结论:
- 在COVID-19患者中的特定IgG抗体是长期存在的,并且受到皮质类固醇治疗的最小影响.
- 发病后一周的IgM水平可以作为COVID-19严重程度和氧气需求的预测指标.
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