活跃的中枢神经系统在健康和内毒性猪中输送氧化
Frida Bällgren1, Tilda Bergfast2, Aghavni Ginosyan2
1Translational Pharmacokinetics/Pharmacodynamics Group (tPKPD), Department of Pharmacy, Uppsala University, Husargatan 3, 752 37, Uppsala, Sweden. frida.ballgren@farmaci.uu.se.
Fluids and barriers of the CNS
|October 24, 2024
概括
这项研究表明,猪积极地将氧化运输到大脑中,大脑间歇性液体中的度高于血. 这种在血脑屏障上的活性药物吸收即使在炎症期间也保持一致.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
- 药物运输 药物运输 药物运输
背景情况:
- 在动物以外的物种中,研究大脑屏障中的活性药物吸收对于人类翻译至关重要.
- 氧化穿过血脑屏障 (BBB) 和血脑脊髓液 (CSF) 屏障的运输需要进一步阐明.
研究的目的:
- 为了检查猪中活性氧化的大脑吸收,猪是一种高于动物的物种.
- 了解通过质子结合有机阴离子 (H+/OC) 反载体在健康和炎症中的药物输送的跨物种翻译.
- 评估腰部CSF度作为大脑中不结合的间歇液 (ISF) 的代理.
主要方法:
- 微透析研究在健康和内毒性猪.
- 同时监测血液,额叶皮层ISF,侧心室 (LV) CSF和腰部CSF中未结合的氧化的度.
- 使用脂多糖 (LPS) 诱导炎症以评估药物运输的变化.
主要成果:
- 未结合的大脑ISF氧的度高于血 (Kpuu,大脑=2.5),支持通过H+/OC反载体在BBB的活性运输.
- 在血液-中枢神经液屏障 (Kpuu,LV) 中也观察到活跃吸收.
- 尽管LPS引起的炎症和生理变化,但BBB的氧化吸收在很大程度上保持不变.
结论:
- 氧化在猪BBB和血液-CSF屏障中表现出活跃的运输.
- 腰椎骨髓液度可以作为中枢神经系统暴露的可靠指标.
- 研究结果为将中枢神经系统药物输送策略转化为人类临床环境提供了关键数据.
相关概念视频
The Parasympathetic Nervous System
99.0K
Overview
99.0K
Neurotransmitters
9.8K
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
9.8K
Gross Anatomy of the Lungs
6.2K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
6.2K
Neural Control of Respiration
5.4K
The neural regulation of respiration is a meticulously coordinated process primarily controlled by the respiratory centers located within the brainstem. These centers, composed of specialized neurons, transmit nerve impulses that control the contraction and relaxation of our respiratory muscles.
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
Respiratory Centers in the Brainstem
Two primary areas comprise the respiratory center: the medullary respiratory center in the medulla oblongata and the pontine respiratory group in the pons. The...
5.4K
Physiology of Respiration II: Neurogenic Control of Respiration
2.9K
The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
2.9K
Neurotransmitters
3.9K
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
3.9K


