在一个活跃的EAE模型中,脊髓中枢液流量的损伤在免疫细胞透之前
Li Xin1, Adrian Madarasz1, Daniela C Ivan1
1Theodor Kocher Institute, University of Bern, Freiestrasse 1, Bern, CH-3012, Switzerland.
Journal of neuroinflammation
|October 24, 2024
概括
在实验性自身免疫脑膜炎 (EAE) 的早期,脊柱下关节空间 (SAS) 中的大脑脊髓液 (CSF) 的流动受损. 这种与纤维素相关的脊髓中枢液流动障碍可能作为白膜疾病的成像生物标志物.
科学领域:
- 神经免疫学 神经免疫学
- 脑脊液动力学 脑脊液动力学
- 多发性硬化症的病理生理学
背景情况:
- 在多发性硬化症 (MS) 和其动物模型实验性自身免疫脑膜炎 (EAE) 期间,免疫细胞和蛋白质的积累发生在脑下空间 (SAS).
- 这些病理变化的影响大脑脊髓液 (CSF) 在脊柱SAS内的流动仍然在很大程度上未知.
研究的目的:
- 为了调查脊柱中枢神经液的体积流在EAE期间是否发生变化.
- 为了确定早期病理变化的潜在的成像生物标志物在leptomeninges.
主要方法:
- 肠道近红外 (NIR) 成像与EAE模型中的他的病理学分析相结合.
- 在脊柱SAS中测量了CSF标记物流量,并与疾病进展和组织病理相关联.
主要成果:
- 在EAE发作之前观察到脊髓中枢神经的大量流量显著受损,持续到疾病的高峰阶段.
- 脊髓中枢液流动障碍与纤维素聚合物的出现相吻合,但先于免疫细胞透和glia limitans superficialis分解.
- 在整个疾病过程中,骨CSF流向宫淋巴结的流量保持不变.
结论:
- 在EAE中,脊髓中核液流是早期和持续受损的.
- 脊髓中枢液流失是一个敏感的成像生物标志物,用于在神经炎症性疾病 (如MS) 期间,在勒普托内早期的病理变化.
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