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Updated: Jun 9, 2025

Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury
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Promotion of Survival and Differentiation of Neural Stem Cells with Fibrin and Growth Factor Cocktails after Severe Spinal Cord Injury

Published on: July 27, 2014

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使用LOCAS-iPSCs-NSCs在SCI大鼠中促进神经再生和运动功能的恢复

Gang Xu1,2, Rui Ge3,4, Chunli Zhang5,6

  • 1Department of Orthopaedics, First Affiliated Hospital of Dalian Medical University, Dalian, 116011, Liaoning Province, China. xugang@dmu.edu.cn.

Stem cell research & therapy
|October 24, 2024
PubMed
概括

这项研究开发了一种与干细胞结合的新型支架 (LOCAS),用于治疗大鼠脊髓损伤 (SCI). 治疗显著改善了运动功能和神经再生,为临床应用提供了希望.

关键词:
生物材料是一种生物材料.原蛋白聚合物 的聚合物.诱导的多能干细胞干细胞神经干细胞的神经干细胞脊髓损伤导致的脊髓损伤组织工程是组织工程.

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Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord20:14

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相关概念视频

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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