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Updated: Jun 9, 2025

Monitoring of Ubiquitin-proteasome Activity in Living Cells Using a Degron dgn-destabilized Green Fluorescent Protein GFP-based Reporter Protein
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Published on: November 10, 2012

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通过ubiquitin蛋白酶体系统功能障碍对NDRG1的上调加剧了神经退行症

Tomonori Hoshino1,2, Atsushi Mukai1,3, Hirofumi Yamashita1,4

  • 1Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8503, Japan.

Molecular brain
|October 24, 2024
PubMed
概括

蛋白质质量控制 (蛋白质稳定) 的受损有助于衰老和神经退行性疾病,如ALS. 这项研究确定NDRG1是一种由蛋白质稳定功能障碍上调的蛋白质,诱导细胞死亡并可能标志着疾病的进展.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.细胞死亡 细胞死亡在 NDRG1 中,神经退行发生神经退行.蛋白质酶体是一种蛋白质酶体.在Psmc4 (Rpt3) 中使用.

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