印度2岁以下儿童内肠胎的传染病因学:一个匹配的病例控制分析
Ira Praharaj1,2, Samarasimha Nusi Reddy1, Nayana Prabhakaran Nair1
1The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Gut pathogens
|October 24, 2024
概括
肠道感染,如腺病毒C和肠道病毒,与印度儿童的肠接有关. 接种罗塔病毒疫苗并没有显示这种情况的风险增加.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 肠道感染是儿童肠接的疑似原因之一.
- 罗塔病毒疫苗接种与某些地区内肠胎的轻微增加有关.
- 这项研究调查了在印度推出Rotavac后的内,检查了病原体的关联.
研究的目的:
- 评估印度儿童的肠道病原体和肠道受精之间的关联.
- 为了评估在轮状病毒疫苗接种后发生肠分泌的风险.
- 为了确定人群归因分数 (PAF) 已识别的肠病原体的内肠异常.
主要方法:
- 在印度的一项医院监测计划中进行了一项病例控制研究.
- 来自272例内肠胎病例和272例匹配对照 (2年以下) 的便样本使用分子测试进行了分析.
- 使用条件后勤回归和PAF计算来评估病原体关联.
主要成果:
- 亚地诺病毒C血清型和肠道病毒在患有内肠异位症的儿童中更为普遍.
- 腺病毒C (aOR=1.74) 和肠道病毒 (aOR=1.77) 显示出与内肠置有显著的关联.
- 罗塔病毒没有被发现与增加肠道内的风险有关.
结论:
- 亚地诺病毒C血清型和肠道病毒与印度儿童的内受精有显著的联系.
- 在本研究人群中,罗塔病毒与肠道受精风险无关.
- 在该地区,腺病毒C和肠道病毒占肠异常病例的很大比例.
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