围产期暴露于异生菌与出生时体积的关联
Katy Valeria De Santiago-Rodríguez1, Alejandro Aarón Peregrina-Lucano2, Fernando Jaramillo-Arriaga3
1Basic Science Center, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.
概括
孕妇接触农药和化物与新生儿脏体积降低有关. 这一发现表明,由于环境毒素,婴儿可能会受到损伤.
科学领域:
- 环境健康 环境健康
- 儿科脏病学 儿科脏病学
- 毒理学 毒理学 毒理学
背景情况:
- 墨西哥的阿瓜斯卡利昂特斯在年轻成年人中出现功能衰竭的发病率最高.
- 低脏捐赠是这种高患病率的一个可疑因素.
- 这项研究调查了产前暴露于异生菌和出生时体积减少之间的联系.
研究的目的:
- 评估怀孕期间暴露于异生菌与新生儿体积低 (KV) 之间的关联.
- 为了确定可能影响胎儿脏发育的特定的异生菌.
- 探索将异生菌暴露与脏异常联系在一起的潜在机制.
主要方法:
- 一项横截面的观察性研究,涉及299名没有并发症的预产期孕妇.
- 收集母亲的尿液 (MU),胎液 (AF) 和新生儿的尿液 (NU) 以进行外源生物分析.
- 使用先进的分析技术 (ICP-MS,HPLC,电位计) 量化金属,非金属,农药和化物.
- 根据身体表面积调整的体积 (TKVBS) 通过脏超声波来确定.
主要成果:
- 在母体样本和新生儿尿液中,暴露于农药 (甲基,2,4-D) 和化物与第五百分位以下的TKVBS显著相关.
- 特定的几率比率突出显示了在AF,MU和NU中与农药和化物暴露相关的风险增加.
- 农药暴露与电解质和微量元素度升高相关,这表明管可能受损.
结论:
- 产前接触农药和化物与新生儿脏体积减少有关.
- 与农药暴露相关的电解质和微量元素的观察到的损失表明近接管道病变的发展.
- 研究结果强调了环境异生菌对早期发育和潜在的长期健康影响的关键影响.
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