鉴定循环微生物DNA及其与糖尿病病患者功能相关性的鉴定
Hoang Thuy Linh1, Megumi Oshima1, Keisuke Sako1
1Department of Nephrology and Rheumatology, Kanazawa University, Japan.
Nephrology (Carlton, Vic.)
|October 24, 2024
概括
在糖尿病病 (DKD) 患者的血液中发现了Klebsiella oxytoca基因. 它的存在与功能下降相关,这表明它可能是DKD进展的生物标志物.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢疾病 代谢疾病
背景情况:
- 肠道微生物群在糖尿病病 (DKD) 的进展中起着重要作用.
- 细菌产品可以表明特定的伤害或影响DKD.
- 特定细菌基因在DKD中的存在和影响需要进一步研究.
研究的目的:
- 检查Klebsiella oxytoca基因在DKD患者的循环中的存在和贡献.
- 研究K. oxytoca基因水平与DKD的临床特征之间的关系.
主要方法:
- 从健康的参与者和患有DKD的患者收集了血液样本,包括那些接受血液透析和没有糖尿病的CKD患者.
- 用滴滴数字PCR检测细菌衍生的DNA,特别是16SrDNA和K.oxytoca基因.
- 在K. oxytoca基因水平和临床参数之间进行了相关性分析.
主要成果:
- 在DKD患者的血液中发现了K. oxytoca基因.
- 血液中K.oxytoca拷贝的增加和K.oxytoca/16SDNA比率与较高的肌素和BUN以及较低的eGFR相关.
- 基因氧托卡水平与中性粒细胞和淋巴细胞数量的改变以及中性粒细胞与淋巴细胞比率的增加有关.
结论:
- 在循环中的K. oxytoca基因的存在可以作为生物标志物.
- 这种生物标志物反映了DKD患者的功能下降.
相关概念视频
01:20Renal Corpuscle
1.7K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.7K
01:12Internal Anatomy of the Kidney
1.4K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.4K
01:10Nephrons
2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K