含比斯的四次治疗的最佳持续时间用于 Helicobacter pylori 根除:系统性审查和元分析
Miao Duan1,2,3, Qingzhou Kong1,2,3, Hui Wang1,2,3
1Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Helicobacter
|October 24, 2024
概括
10天的含四倍疗法 (BcQT) 疗程有效地消除了Helicobacter pylori,提供与14天治疗相比的结果. 较短的持续时间显示了类似的疗效和安全性.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 临床药理学 临床药理学
背景情况:
- 杆菌 (H. pylori) 感染是全球日益严重的健康问题,原因是抗生素耐药性增加.
- 建议使用含四倍疗法 (BcQTs),但最佳治疗持续时间仍在争论中.
- 这项研究评估了短期 (7或10天) BcQT 疗效与标准的14天疗程相比.
研究的目的:
- 为了比较短期 (7或10天) BcQT与H. pylori根除的标准14天BcQT的临床疗效.
- 分析不同治疗持续时间的根除率,不良影响和患者遵守情况.
- 调查抗生素组合和酸抑制剂对治疗结果的影响.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析,公布时间为2024年6月20日.
- 搜索了主要的数据库:PubMed,Embase,科学网和科克兰图书馆.
- 计算的总结风险比率 (RRs) 和95%信心区间 (CI) 对于根除率,不良事件和合规性,遵循PRISMA指南.
主要成果:
- 包括15项试验,包括4505名患者. 总体而言,短期BcQT (7或10天) 的根除率略低于14天治疗 (RR 0.96).
- 然而,10天的BcQT显示了与14天疗程 (RR 0.98) 相当的根除率.
- 环素-美트로尼达结合剂和竞争性酸阻断剂在短期和14天组中表现出类似的疗效. 不良影响和遵守是可比的.
结论:
- 10天的BCQT疗程似乎是H.pylori根除的最佳持续时间.
- 选择抗生素时应考虑区域性H. pylori耐药性模式,以提高有效性.
- 短期BcQT方案的疗效和安全性与标准的14天治疗方案相提并论.
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