相关实验视频
Updated: Jun 9, 2025

04:49
Technique for Intranasal Administration of α-Synuclein Aggregates
Published on: November 8, 2024
395
在prodromal α-synucleinopathies中的岛屿单氨基缺乏症
Andrea Pilotto1,2,3,4, Alice Galli1,3, Cinzia Zatti1,2,3
1Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, 25123, Italy.
Annals of clinical and translational neurology
|October 24, 2024
概括
在异常性REM睡眠行为障碍 (iRBD) 中,岛内单胺结合的改变与帕金森病或勒维体痴呆症的进展有关. 这一发现有助于在未来治疗中对患者进行分层.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 阿尔法-同核蛋白病变,包括异常REM睡眠行为障碍 (iRBD),帕金森病 (PD) 和患有莱维体 (DLB) 的痴呆症,涉及渐进的神经退行.
- 对于及时干预至关重要的是早期识别那些面临转变为PD或DLB的高风险的iRBD个体.
研究的目的:
- 调查123I-FP-CIT全脑SPECT成像,以确定与对照组相比,iRBD,PD和DLB患者的单氨基缺陷.
- 评估iRBD中岛屿单氨基缺陷与临床转换风险之间的关联.
主要方法:
- 利用了来自两个队列 (布雷西亚大学和罗马大学Tor-Vergata) 的数据,其中包括184名参与者 (45名iRBD,47名PD,42名DLB,50名对照).
- 进行了神经学,临床和123I-FP-CIT SPECT成像评估.
- 长期监测iRBD患者并使用考克斯回归分析来确定表转化风险.
主要成果:
- 患有iRBD的患者被分为RBD-DAT- (n=32) 和RBD-DAT+ (n=13) 的类别.
- 在RBD-DAT-中显示了早期的左胰岛参与,这在RBD-DAT+中更为明显,在PD和DLB患者中更为明显.
- 在iRBD患者中,岛内单氨基缺陷与转化风险增加3.387倍有关.
结论:
- 在iRBD中改变的岛屿单氨基结合是转化为PD或DLB的显著预测因素.
- 这些研究结果表明,123I-FP-CIT SPECT图像对胰岛素的成像可以帮助对针对性治疗的IRBD患者进行分层.
相关概念视频
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Alzheimer's Disease: Overview
449
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
449
Parkinson's Disease: Overview
486
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
486
Amyloid Fibrils
9.3K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.3K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
483
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
483

