周围手术系统疗法,当前的范式和正在进行的临床试验在上道泌尿器癌的临床试验
Raj R Bhanvadia1, Zine-Eddine Khene, Vitaly Margulis
1Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Current opinion in urology
|October 24, 2024
概括
建议在高度上道泌尿器官癌症中使用新辅助性思普拉丁化疗. 基于的辅助化疗是符合条件的患者手术后的选择,正在研究新的疗法.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医学瘤学 医学瘤学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 上道泌尿道癌 (UTUC) 是一种罕见的恶性瘤.
- 系统疗法在管理UTUC方面起着至关重要的作用,特别是在外科手术期间.
研究的目的:
- 审查UTUC的现有和新兴的外科手术期间全身疗法选择.
- 评估支持UTUC新辅助和辅助化疗的证据.
主要方法:
- 审查现有的文献和临床试验数据.
- 在UTUC中分析基于西斯普拉丁的化疗证据.
- 对新型全身疗法的正在进行的试验进行评估.
主要成果:
- 新辅助性西斯普拉丁化疗对高等级的UTUC有所支持.
- 基于的辅助化疗有证据表明,脏切除术后的侵入性UTUC.
- 有关功能和手术后金资格存在担忧.
结论:
- 目前的证据支持新辅助性思普拉丁和辅助性基化疗用于UTUC在选定的患者.
- 目前正在进行的试验正在调查UTUC的免疫疗法和抗体药物合物.
- 新型非基疗法可能为UTUC提供未来的治疗选择.
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