急性呼吸道感染的流行病学和病理学特征
Mengyun Xu1, Wenying He2, Songsong Xie2
1Shihezi University School of Medicine, Shihezi, Xinjiang, China.
概括
这项研究确定了人类呼吸道同胞病毒 (hRSV),SARS-CoV-2和人类腺病毒 (HAdV) 作为Shihezi的关键病原体.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 急性呼吸道感染 (ARI) 在全球范围内构成了重大公共卫生挑战.
- 了解ARI的特定流行病学特征和致病原体对于有效的控制策略至关重要.
- 以前在新疆石河市进行的研究尚未全面详细介绍ARI的病原体概况.
研究的目的:
- 在新疆石河市调查急性呼吸道感染 (ARI) 的流行病学特征和病原体谱.
- 开发和验证贝叶斯区分函数用于ARI的主要病原体感染的分类.
- 为该地区的ARI预防和临床管理提供科学基础.
主要方法:
- 从2020年1月到2023年6月,对2020年1月至2023年6月在石河西大学第一附属医院住院的ARI病例进行了回顾性分析.
- 通过对患者样本进行实验室检测来检测病原体.
- 开发和验证用于病原体识别的贝叶斯区分函数.
主要成果:
- 在2110例ARI病例中,595例 (34.27%) 检测出至少一种病原体.
- 病毒病原体 (27.47%) 比细菌病原体 (6.51%) 更为普遍.
- 发现的关键病原体包括人类呼吸道同胞性病毒 (hRSV),SARS-CoV-2,人类腺病毒 (HAdV),Klebsiella pneumoniae,Haemophilus influenzae和金黄色葡萄球菌.
- hRSV在急性支气管炎中占主导地位,而SARS-CoV-2在严重肺炎中占主导地位.
- 贝叶斯判别函数的初始验证准确率为74.9%,交叉验证准确率为63.7%.
结论:
- hRSV,SARS-CoV-2和HAdV是主要的病毒病原体,在石河市负责ARI.
- 细菌感染与高C反应蛋白和中性粒细胞百分比相关.
- 贝叶斯区分函数显示出有助于诊断和分类ARI病原体的潜力,儿童的检测率更高.
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