Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Atomic Nuclei: Types of Nuclear Relaxation01:28

Atomic Nuclei: Types of Nuclear Relaxation

268
Nuclear relaxation restores the equilibrium population imbalance and can occur via spin–lattice or spin–spin mechanisms, which are first-order exponential decay processes.
In spin–lattice or longitudinal relaxation, the excited spins exchange energy with the surrounding lattice as they return to the lower energy level. Among several mechanisms that contribute to spin–lattice relaxation, magnetic dipolar interactions are significant. Here, the excited nucleus transfers...
268
Mitochondria01:37

Mitochondria

11.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
11.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Modifiable Risk Factors and Attributable Ischemic Heart Disease Mortality in US States, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023.

JAMA cardiology·2026
Same author

Role of Perfusion Parameters on Outcomes and Safety of Endovascular Therapy in Posterior Cerebral Artery Stroke.

Stroke·2026
Same author

MAD-MT Score: A Tool to Optimize Patient Selection for Mechanical Thrombectomy in Distal Vessel Occlusions.

Stroke·2026
Same author

Multiparametric MRI Model Predicts Parenchymal Hematoma in Acute Ischemic Stroke After Reperfusion.

AJNR. American journal of neuroradiology·2026
Same author

Dysfunctional large-scale networks linking PTSD and cognitive impairment.

Journal of psychiatric research·2026
Same author

Machine Learning for Distal Medium-Vessel Occlusion Detection: Advances, Challenges, and Future Directions.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2026

相关实验视频

Updated: Jun 9, 2025

Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration
05:30

Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration

Published on: May 19, 2023

1.2K

代谢物T2的放松时间在成年人一生中在一个大型多站点队列中减少.

Kathleen E Hupfeld1,2, Saipavitra Murali-Manohar1,2, Helge J Zöllner1,2

  • 1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Magnetic resonance in medicine
|October 24, 2024
PubMed
概括

衰老显著改变代谢物T2值,影响体内MRS量化. 未来的研究应该使用特定年龄的T2估计,以提高准确性.

关键词:
T2放松时间时间TE系列的TE系列.健康的衰老健康的衰老磁共振光谱学 (MRS) 是一种技术.代谢产物的代谢产物

更多相关视频

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

7.0K
Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
07:33

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

352

相关实验视频

Last Updated: Jun 9, 2025

Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration
05:30

Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration

Published on: May 19, 2023

1.2K
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
15:10

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

7.0K
Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
07:33

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

352

科学领域:

  • 神经成像是一种神经成像.
  • 生物物理学的生物物理.
  • 代谢学 代谢学 代谢学

背景情况:

  • 精确的体内磁共振光谱 (MRS) 量化依赖于精确的放松校正.
  • 当前的MRS协议通常假定整个生命中代谢物T2值是恒定的,忽略了与年龄相关的变化.
  • 之前的研究表明,关键代谢物的T2随着衰老而变化,需要进行全面的调查.

研究的目的:

  • 为了研究代谢物T2值与参与者年龄之间的相关性,在一个大型的多站点队列中.
  • 为了确定与年龄相关的T2变化是否会影响大脑不同区域的代谢物量化.
  • 为提高MRS准确性提供特定年龄的T2估计方程.

主要方法:

  • 在五个年龄十年 (18-60岁以上) 招募了101名参与者.
  • 从半圆中心 (CSO) 和后带皮层 (PCC) 获取了八个回声时间 (TE) 的PRESS MRS数据.
  • 使用Osprey的量化代谢物振幅和通过拟合指数衰变曲线估计的T2.

主要成果:

  • 年龄较大与tNAA,tCr,tCho,组织水,mI和Glx的T2较短相关 (p <0.05,FDR校正).
  • 即使在控制皮层缩后,这些关联仍然存在.
  • 观察到T2值的区域差异,一些代谢物的CSO和其他代谢物的PCC的T2较长.

结论:

  • 代谢物T2值随着年龄的增长而显著变化,影响MRS量化准确度.
  • 特定年龄的T2估计对于可靠的代谢物度测量至关重要.
  • 该研究为特定年龄的T2值提供了方程,以加强未来的3T MRS研究.