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代谢物T₂的放松时间在成年人一生中在一个大型多站点队列中减少

Kathleen E Hupfeld^1,2, Saipavitra Murali-Manohar^1,2, Helge J Zöllner^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Magnetic resonance in medicine

|October 24, 2024

概括

衰老显著改变代谢物T2值,影响体内MRS量化. 未来的研究应该使用特定年龄的T2估计,以提高准确性.

科学领域:

神经成像是一种神经成像.
生物物理学的生物物理.
代谢学代谢学代谢学

背景情况:

精确的体内磁共振光谱 (MRS) 量化依赖于精确的放松校正.
当前的MRS协议通常假定整个生命中代谢物T2值是恒定的,忽略了与年龄相关的变化.
之前的研究表明,关键代谢物的T2随着衰老而变化,需要进行全面的调查.

研究的目的:

为了研究代谢物T2值与参与者年龄之间的相关性,在一个大型的多站点队列中.
为了确定与年龄相关的T2变化是否会影响大脑不同区域的代谢物量化.
为提高MRS准确性提供特定年龄的T2估计方程.

主要方法:

在五个年龄十年 (18-60岁以上) 招募了101名参与者.
从半圆中心 (CSO) 和后带皮层 (PCC) 获取了八个回声时间 (TE) 的PRESS MRS数据.
使用Osprey的量化代谢物振幅和通过拟合指数衰变曲线估计的T2.

主要成果:

年龄较大与tNAA,tCr,tCho,组织水,mI和Glx的T2较短相关 (p <0.05,FDR校正).
即使在控制皮层缩后,这些关联仍然存在.
观察到T2值的区域差异,一些代谢物的CSO和其他代谢物的PCC的T2较长.

结论:

代谢物T2值随着年龄的增长而显著变化,影响MRS量化准确度.
特定年龄的T2估计对于可靠的代谢物度测量至关重要.
该研究为特定年龄的T2值提供了方程,以加强未来的3T MRS研究.

关键词:

T2放松时间时间 TE系列的TE系列.健康的衰老健康的衰老磁共振光谱学 (MRS) 是一种技术.代谢产物的代谢产物

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