在2型糖尿病中,IGF-1/IGFBP-3比率对甲状腺结节的预测值
1Department of Endocrinology, The Second Hospital of Jilin University, Changchun, China.
Frontiers in endocrinology
|October 24, 2024
概括
IGF-1/IGFBP-3比率显示出在2型糖尿病患者中预测甲状腺结节的潜力. 这种比率和其他因素一起,可以帮助识别患甲状腺结节的风险较高的人.
科学领域:
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
- 在瘤学瘤学.
背景情况:
- 2型糖尿病 (T2DM) 与各种并发症的风险增加有关.
- 甲状腺结节 (TNs) 是常见的,它们与T2DM的关联需要进一步调查.
- 了解T2DM患者中TN的预测标记可以帮助早期检测和管理.
研究的目的:
- 评估胰岛素样生长因子1 (IGF-1) 与IGF结合蛋白3 (IGFBP-3) 的比对T2DM患者甲状腺节块存在的预测能力.
- 在这个患者群体中确定与甲状腺结节相关的独立风险因素和保护因素.
主要方法:
- 进行了一项观察性研究,涉及122名T2DM患者.
- 甲状腺结节的状况被评估使用超声波.
- 采用接收器操作特征 (ROC) 曲线分析和多变量逻辑回归来分析预测值和风险因素.
主要成果:
- 在122名患者中,62.3%患有甲状腺结节.
- 结合IGF-1,IGFBP-3和它们的摩尔比率显示出一个预测值 (AUC = 0.619).
- 独立的危险因素包括糖尿病持续时间,年龄,禁食血葡萄糖 (FPG),禁食胰岛素 (FINS),甲状腺刺激激素 (TSH),IGF-1和IGFBP-3). IGF-1/IGFBP-3比率是一个保护因素.
结论:
- 结合IGF-1,IGFBP-3和它们的摩尔比值的评估,可能比单个标志物更能为T2DM患者的TN提供更好的预测价值.
- 糖尿病的持续时间,年龄,FPG,FINS,TSH,IGF-1,IGFBP-3和IGF-1/IGFBP-3的摩尔比率独立地与T2DM中的甲状腺结节有关.
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