多发性硬化症:新出现的流行病学趋势和重新定义临床过程
Emilio Portaccio1, Melinda Magyari2, Eva Kubala Havrdova3
1Department of NEUROFARBA, Unviersity of Florence, Florence, Italy.
The Lancet regional health. Europe
|October 24, 2024
概括
多发性硬化症 (MS) 越来越多地影响着老年人,进展独立于复发活动 (PIRA) 现在被视为残疾的主要驱动因素. 了解PIRA对于不断发展的MS临床理解和管理至关重要.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 是一种慢性,炎症性,神经退行性疾病,影响中枢神经系统.
- 多发性硬化是年轻人神经障碍的主要原因,其全球流行率和发病率正在增加.
- 最近的趋势显示,多发性硬化症患病率向老年人群转移.
研究的目的:
- 提供欧洲MS不断变化的临床过程和流行病学趋势的概述.
- 专注于不依赖复发活动的进展 (PIRA) 作为潜在的残疾获得的主要机制.
- 讨论定义和识别PIRA的挑战及其对MS分类的影响.
主要方法:
- 审查传统的临床过程描述和MS的欧洲流行病学趋势.
- 对进展独立于复发活动 (PIRA) 概念的分析.
- 讨论正在进行的研究,PIRA的不同定义,并评估隐藏的临床表现.
主要成果:
- 有证据表明,应将多发性硬化症视为一个连续性,复发性和渐进性特征在早期并存.
- 不同于复发活动的进展 (PIRA) 越来越被认为是残疾累积的重要因素.
- 对PIRA的定义和识别带来了持续的挑战.
结论:
- 重新考虑MS作为一个连续性的挑战其临床过程的传统观点.
- 评估隐藏的临床表现对于量化PIRA和改善患者管理至关重要.
- 对PIRA的新理解对于未来的MS临床分类和治疗策略至关重要.
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