支气管喘与正常的1秒强迫呼气体积 (FEV1) 相比低FEV1
Akihiko Ohwada1,2, Hiroko Kitaoka3
1Ohwada Clinic, Ichikawa, Japan.
Journal of thoracic disease
|October 24, 2024
概括
咳变异性喘 (CVA) 在正常肺功能 (FEV1 ≥90%) 的患者中不常见. 患有正常FEV1的喘患者对治疗反应良好,表明轻度喘,但与减少FEV1的患者相比,显示出不同的标记者配置文件.
科学领域:
- 肺部病理学 肺部病理学
- 呼吸系统医学 呼吸系统医学
- 临床免疫学临床免疫学
背景情况:
- 咳变异性喘 (CVA) 呈现为咳作为唯一症状和正常的肺功能,特别是1秒内强制呼吸量 (FEV1).
- 在正常FEV1的喘患者中,CVA的患病率尚不清楚.
- 这项研究旨在确定正常FEV1患者仅咳症状的发生率,并将其与典型的喘患者进行比较.
研究的目的:
- 为了评估咳的发病率作为唯一的喘患者的症状与正常的FEV1 (≥90%预测).
- 为了比较正常FEV1的喘患者和低FEV1 (预测<90%) 的喘患者之间的临床特征和治疗反应.
- 研究不同FEV1群体中症状改善与FeNO,乙氨基和IgE等生物标志物之间的关系.
主要方法:
- 329名未接受过治疗的喘患者被分为正常FEV1 (≥90%) 和低FEV1 (<90%) 组.
- 评估视觉模拟尺度 (VAS) 咳和呼吸不良,FEV1和分数呼出的氧化 (FeNO) 对吸入性皮质类固醇/长效β2激动剂 (ICS/LABA) 治疗的反应.
- 症状的相关变化与FEV1,FeNO,外围乙氨基酸细胞数和血清IgE相关.
主要成果:
- 只有8.6%的正常FEV1组有咳而没有呼吸障碍,这表明CVA候选人很少.
- 两组患者在ICS/LABA治疗中都出现了症状改善,但低FEV1组的呼吸障碍VAS得分仍然较高.
- 与低FEV1组相比,正常FEV1患者在治疗前具有较低的乙氨基酸,IgE和FeNO,治疗后FEV1改善较少.
结论:
- 具有正常FEV1的喘患者,包括潜在的CVA病例,代表轻度喘表型.
- 这些患者对ICS/LABA治疗反应良好,症状改善与FEV1变化相关.
- 虽然整体症状相似,但症状改善和Th2标志物之间的关系在正常和低FEV1组之间有所不同.
相关概念视频
Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma: Pathogenesis and Management
361
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
361
Factors Affecting Pulmonary Ventilation
1.2K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.2K


