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Updated: May 12, 2026

Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit
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通过识别和锁定所有六个pH开关来设计一个裂开的,预注射稳定的B型流感病毒血蛋白

Jarek Juraszek1, Fin J Milder1, Xiaodi Yu2

  • 1Janssen Vaccines & Prevention BV, 2333 CN Leiden, The Netherlands.

PNAS nexus
|October 24, 2024
PubMed
概括

改善B型流感病毒疫苗需要稳定的输血前血凝素 (HA). 研究人员通过准pH敏感区域来增强HA的稳定性,从而实现了更好的疫苗开发.

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...