在患有性单侧脑的幼儿中,体育/职业疗法后扩散MRI和临床运动功能的变化
Adam Bernstein1, Heidi Pottinger2,3, Jeffrey Miller4
1Department of Biomedical Engineering, University of Arizona, Tucson, AZ, United States.
Frontiers in neurology
|October 24, 2024
概括
扩散权重核磁共振 (DMRI) 显示,在接受治疗的大脑麻 (CP) 的儿童中,有潜力跟踪大脑变化. 虽然临床运动功能有所改善,但DMRI检测到微妙的微观结构变化,尽管与FA值没有一致的相关性.
科学领域:
- 神经成像是一种神经成像.
- 儿科神经学 儿科神经学
- 康复科学 康复科学 康复科学
背景情况:
- 大脑 (CP) 影响儿童的运动功能.
- 物理和职业治疗的目的是改善运动技能和神经可塑性.
- 评估治疗诱导的脑部变化在患有CP的幼儿是具有挑战性的.
研究的目的:
- 评估扩散权重磁共振成像 (DMRI) 是否可以在治疗36周后检测CP儿童大脑中的微观结构和连接性变化.
- 确定这些成像发现是否与改善运动功能的临床测量相关.
主要方法:
- 长度研究涉及5名患有CP的儿童.
- 在基线和36周治疗后进行的解剖MRI和DMRI.
- 扩散张力成像 (DTI) 和受约束的球形解卷 (CSD) 用于分析白质微观结构 (FA) 并生成脑脊道 (CST) 轨道图.
主要成果:
- 所有孩子在36周的治疗后都表现出改善的运动功能.
- 解剖MRI显示没有显著的变化.
- 中枢神经管道图显示了微妙的差异,表明改变了微观结构/连接性,但在中枢神经管道沿线的分数异构 (FA) 值没有显著变化.
- 观察到高个体间的变化.
结论:
- 纵向DMRI在患有CP的幼儿中是可行的,并可能监测白质神经质变化.
- 运动功能的临床改善与CST沿线的FA测量并不一致相关.
- 尽管存在变异性和相关性挑战,DMRI为评估儿科CP的治疗诱导的大脑变化提供了一个有前途的工具.
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