Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

1
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
1
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

1
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
1
Atherosclerosis II: Clinical manifestations and prevention01:27

Atherosclerosis II: Clinical manifestations and prevention

1
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
1
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

3
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

1
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
1
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

3
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
3

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Elevated IL-6 receptor expression on CD4+ T cells contributes to the increased Th17 responses in patients with chronic hepatitis B.

Virology journal·2011
Same author

Neurochemical plasticity of nitric oxide synthase isoforms in neurogenic detrusor overactivity after spinal cord injury.

Neurochemical research·2011
Same author

[Clinical significance of 5-HT and DA levels in serum and cerebrospinal fluid of the patients with delayed encephalopathy after acute carbon monoxide poisoning].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2011
Same author

Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1(-/-) cells.

American journal of physiology. Cell physiology·2011
Same author

[The association between HBV genotyping and clinical characteristics and expression of TH1/TH2 cytokines].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology·2011
Same author

Bis[5-(2-pyrid-yl)pyrazine-2-carbonitrile]-silver(I) tetra-fluorido-borate.

Acta crystallographica. Section E, Structure reports online·2011
Same journal

PER1 reduces HIF-1α nuclear accumulation and modulates vascular remodeling in hepatocellular carcinoma.

Molecular and cellular biochemistry·2026
Same journal

FCGR2A promoter variant reveals shared genetic susceptibility between IBD and stroke.

Molecular and cellular biochemistry·2026
Same journal

Chlamydia psittaci induces GSDME-mediated pyroptosis via the ROS-JNK signaling pathway.

Molecular and cellular biochemistry·2026
Same journal

Pentraxin 3 is an inflammation-related biomarker that distinguishes early-stage from mid-advanced cardiovascular-kidney-metabolic syndrome.

Molecular and cellular biochemistry·2026
Same journal

High glucose-induced mitochondrial fission promotes Müller cell activation via suppression of the Hippo pathway.

Molecular and cellular biochemistry·2026
Same journal

Correction to: Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein.

Molecular and cellular biochemistry·2026
查看所有相关文章

相关实验视频

Updated: Jun 9, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.2K

奥米克斯对动脉样硬化的研究.

Kai-Jiang Tian1,2, Yu Yang2, Guo-Shuai Chen3

  • 1Pathology Department, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.

Molecular and cellular biochemistry
|October 24, 2024
PubMed
概括
此摘要是机器生成的。

动脉样硬化 (AS) 是一种慢性炎症性疾病,缺乏有效的治疗方法. 欧米克技术为AS机制和心血管疾病的潜在治疗点提供了新的见解.

关键词:
动脉样硬化是一种动脉样硬化.基因组学就是基因组学.代谢学 代谢学 代谢学微生物组学 微生物组学俄米克斯 (Omics) 是一个电子游戏.蛋白质组学是指蛋白质组学.文字转录学 (Transcriptomics) 是一个学科.

更多相关视频

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

37.1K
Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
07:49

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Published on: February 14, 2025

350

相关实验视频

Last Updated: Jun 9, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.2K
Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

37.1K
Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
07:49

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Published on: February 14, 2025

350

科学领域:

  • 心血管研究研究心血管研究
  • 分子生物学分子生物学
  • 病理生理学 病理生理学

背景情况:

  • 动脉样硬化 (AS) 是一种慢性炎症性疾病,是心血管疾病的基础,以动脉内脏脂质沉积,纤维组织增殖和化为特征.
  • 复杂的AS病原体,包括氧化应激,炎症和脂质变化,仍然不完全理解.
  • 目前对AS的预防和治疗策略有限,这凸显了对新方法的需求.

研究的目的:

  • 在过去十年中,审查omics技术在动脉样硬化研究中的应用和影响.
  • 为了确定目前的状态,挑战,局限性,和未来的前景的omics在理解AS.
  • 以突出通过奥米克斯方法确定AS相关疾病的潜在治疗点.

主要方法:

  • 系统审查过去10年发表的研究文章,重点关注omics技术和动脉样硬化.
  • 分析与AS相关的基因组,转录组,蛋白质组和代谢组研究.
  • 评估AS中omics发现的临床相关性和翻译潜力.

主要成果:

  • 奥米克技术 (基因组学,转录组学,蛋白质组学,代谢组学) 为剖析AS复杂性提供了强大的工具.
  • 在识别与AS相关的分子途径和生物标志物方面取得了重大进展.
  • 在数据集成,验证和临床翻译omics发现方面仍然存在挑战.

结论:

  • 奥米克技术正在彻底改变动脉样硬化研究,为其病理生理学提供了更深入的见解.
  • 需要进一步的研究来克服目前的局限性,并将omics发现转化为有效的临床应用.
  • 通过omics识别的向途径有望为AS和相关心血管疾病开发新的治疗策略.