芬太尼,海洛因,甲基胺和可卡因分析物的度在尿液毒品检测样本中的度
Andrew S Huhn1, Penn Whitley2, B Levi Bolin2
1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA network open
|October 24, 2024
概括
美国药物过量危机显示,芬太尼,甲基胺和可卡因度不断上升. 从2013年到2023年,海洛因水平下降,这表明非法药物暴露的转变以及更新治疗策略的需要.
科学领域:
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
- 法医科学 法医科学 法医科学
背景情况:
- 美国面临着严重的药物过量危机,由非法制造的芬太尼 (IMF),甲基胺和可卡因推动.
- 药物暴露度和患病率显著影响过量服用的风险和治疗的有效性.
研究的目的:
- 从2013年到2023年,量化美国绝对药物暴露度的变化.
- 分析10年来芬太尼,甲基胺,可卡因和海洛因度的趋势.
主要方法:
- 一项横截面研究分析了49个州和DC (2013-2023) 的921,931个尿液药物测试 (UDT) 结果.
- 样本来自使用物质障碍治疗诊所的成年患者.
- 液体染色学-双重质谱法用于测量芬太尼,海洛因,可卡因和甲基胺的肌素正常化度.
主要成果:
- 从2013年到2023年,调整后的尿度对芬太尼 (4.61至38.23 ng/mg),甲基胺 (665.27至3461.59 ng/mg) 和可卡因 (559.71至1122.23 ng/mg) 显著增加.
- 在同一时期,调整后的海洛因度从146.59降至58.36 ng/mg.
- 在美国人口普查部门观察到药物度的地理差异.
结论:
- 芬太尼,甲基胺和可卡因的绝对度明显增加,而海洛因度在2013年至2023年期间下降.
- 这些变化意味着美国非法毒品供应和暴露模式的根本变化.
- 加强对IMF和兴奋剂暴露的监测和有针对性的治疗至关重要.
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