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前列腺切除术后放射治疗时间和长期与健康有关的生活质量.

Sagar A Patel1,2, Dattatraya Patil2, Joseph Smith3

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前列腺切除术后的放射治疗会影响生活质量. 早期或晚期放射治疗时间显示,前列腺癌患者的性,尿道和肠道健康的长期结果相似.

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科学领域:

  • 在瘤学瘤学.
  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 辐射疗法 辐射疗法

背景情况:

  • 根源性前列腺切除术后放射治疗 (RT) 时间对前列腺癌患者长期健康相关生活质量 (HRQOL) 的影响尚不清楚.
  • 患者报告的结果对于评估超出生存率的治疗有效性至关重要.

研究的目的:

  • 在接受RT或未接受RT的男性中评估长期HRQOL至前列腺切除术后15年.
  • 为了比较早期 (<12个月) 和晚期 (≥12个月) 前列腺切除术后的HRQOL结果,RT.

主要方法:

  • 一项前性,多中心的纵向队列研究,涉及1203名接受激进前列腺切除术的男性.
  • 用扩大前列腺癌综合指数测量HRQOL,评估性,尿道,肠道和荷尔蒙领域.
  • 男人被分为仅进行前列腺切除,早期RT和晚期RT组;结果使用混合效应模型进行分析.

主要成果:

  • 与单独进行前列腺切除术相比,前列腺切除术后的RT与性,失禁和尿路刺激HRQOL的显著下降有关.
  • 在早期和晚期RT组之间没有观察到长期HRQOL的显著差异.
  • 与晚期RT组相比,接受早期RT的男性在性,禁欲和尿道刺激得分上的恢复有所改善.

结论:

  • 前列腺切除术后的RT对多个领域的长期HRQOL产生负面影响.
  • RT的时间 (早期与晚期) 似乎不会显著影响长期HRQOL结果.
  • 与延迟的RT相比,早期RT可能在恢复特定HRQOL领域方面提供一些优势.