基于黄的营养补充剂和与年龄相关的黄斑退化风险
Amer F Alsoudi1, Karen M Wai2, Euna Koo2
1Department of Ophthalmology, Baylor College of Medicine, Houston, Texas.
JAMA ophthalmology
|October 24, 2024
概括
基于黄的营养补充剂 (CBNS) 可能会降低患上或进展与年龄相关的黄斑变性 (AMD) 的风险. 这项研究发现,CBNS的使用与较低的AMD发育率,高级AMD和相关的视力损失有关.
科学领域:
- 眼科医生 眼科 眼科
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 与年龄相关的黄斑变性 (AMD) 是老年人视力丧失的主要原因.
- 基于黄的营养补充剂 (CBNS) 具有抗炎和抗氧化特性.
- 在缓解AMD风险和进展方面,CBNS的潜在益处需要进行调查.
研究的目的:
- 调查使用基于的营养补充剂 (CBNS) 与患上或进展与年龄相关的黄斑变性 (AMD) 的风险之间的关联.
主要方法:
- 使用TriNetX网络的电子健康记录进行的回顾性队列研究.
- 使用倾向分数匹配 (PSM) 来控制混变量.
- 患者根据CBNS处方记录使用RxNorm代码进行了分层.
主要成果:
- 使用CBNS与显著较低的非排泄性AMD (RR,0.23),高级AMD/地理缩 (RR,0.11),排泄性AMD (RR,0.28) 和失明 (RR,0.46) 的发病率相关.
- 在患有早期AMD的患者中,CBNS的使用与进展到晚期AMD/地理缩的减少相关 (RR,0.58).
- 这些关联在不同的年龄小组中是一致的.
结论:
- 随后使用CBNS似乎与发展AMD及其进展的风险降低有关.
- 建议进行进一步的研究以验证这些发现,并探索CBNS在AMD管理中的安全性和药物保护机制.
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