新生儿生长激素激增的特征和调节
Daniela O Gusmao1, Ligia M M de Sousa1, Maria E de Sousa1
1Department of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, SP 05508-000, Brazil.
Endocrinology
|October 24, 2024
概括
新生儿生长激素 (GH) 的分泌在小鼠和老鼠中很高,但迅速下降. 这种早期的GH激增需要GH释放激素 (GHRH) 受体,并由体静止素和葡萄糖调节.
科学领域:
- 神经内分泌学神经内分泌学
- 发展生物学 发展生物学
- 激素调节 激素调节 激素调节
背景情况:
- 新生儿生长激素 (GH) 的高分泌在各物种中观察到,但其潜在的神经内分泌机制尚不清楚.
- 了解生命早期的荷尔蒙调节对于发展洞察至关重要.
研究的目的:
- 研究调节高产后GH分泌激增的神经内分泌机制,在小鼠和老鼠.
- 阐明GHRH,体静止素,瘦素和葡萄糖在新生儿GH调节中的作用.
主要方法:
- 在小鼠和老鼠的产后发育过程中测量血液GH水平.
- 基因操纵包括GHRH受体,Sst,GH受体和IGF-1受体的淘汰和淘汰模型.
- 分析下丘脑Sst mRNA和体静止素的神经内分泌终端.
- 评估叶黄素缺乏效应和葡萄糖诱导高血糖的影响.
主要成果:
- 在小鼠中,GH水平在产后第1天达到峰值,并在第17天下降,在老鼠中也有类似的模式 (雌性在P1上更高).
- 在GHRH受体淘汰赛小鼠中,GH激增不存在,但在Sst淘汰赛小鼠中增强.
- 在特定的神经元群体中,GH受体或IGF-1受体的切除会影响GH水平的降低,而不是最初的激增.
- 过高血糖过度刺激新生儿GH分泌,表明葡萄糖调节.
结论:
- 新生儿GH激增并不是通过负反循环来调节的.
- 它需要GH释放激素受体,并由体静止素和血糖水平调节.
- 垂体下垂体的沟通很可能控制了这一关键的生命早期GH激增.
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