感染性支气管炎病毒BR1和大规模疫苗的组合提供了广泛的保护
Hanneke Bataille1, Robert Jan Molenaar1, Gustavo Schaefer2
1Royal GD, Deventer, The Netherlands.
Avian pathology : journal of the W.V.P.A
|October 24, 2024
概括
感染性支气管炎病毒 (IBV) BR1和IBV大规模疫苗的组合提供了对普遍存在的南美IBV菌株的优越保护. 与单独使用IBV BR1相比,这种双重疫苗接种策略显示出更高和更一致的疗效.
科学领域:
- 兽医病毒学 兽医病毒学
- 免疫学 免疫学 免疫学
- 禽类的健康 禽类的健康
背景情况:
- 传染性支气管炎病毒 (IBV) 对全球家禽生产构成重大威胁.
- 新兴和异质IBV菌株需要有效的疫苗接种策略.
- 在南美洲占主导地位的IBV菌株需要特殊保护.
研究的目的:
- 为了评估商业传染性支气管炎病毒 (IBV) BR1疫苗的疗效,单独和与IBV群体疫苗结合使用.
- 评估对一组在南美洲普遍存在的IBV挑战病毒的保护.
- 确定疫苗组合是否符合欧洲药典保护标准.
主要方法:
- 使用商业IBV BR1和IBV 大量疫苗进行了两项疫苗挑战试验.
- 受到了IBV菌株M41,793B,D388 (QX),Q1,巴西-1和变种2的挑战.
- 通过在挑战后评估气管上皮的状活动来衡量有效性.
主要成果:
- 仅IBV BR1疫苗就能对6种IBV挑战菌株提供50-100%的保护 (平均80%).
- 结合IBV BR1和IBV 大量疫苗的组合提供了80-100%的保护 (平均92%).
- 该组合疫苗始终符合欧洲药典的标准,即所有挑战菌株至少有80%的保护.
结论:
- 仅用IBV BR1接种疫苗就能对各种IBV菌株产生相当大的保护.
- 结合IBV BR1和IBV 群体疫苗,对流传的南美IBV菌株提供了更优越,更一致的保护.
- 建议采用双重疫苗的方法,以在该地区对IBV进行全面的保护.
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