表观遗传衰老通过自我报告的种族差异性影响乳腺癌风险
Yanning Wu1, Megan E Miller2,3, Hannah L Gilmore4
1Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America.
PloS one
|October 24, 2024
概括
表观遗传加快年龄与乳腺癌 (BrCa) 风险增加有关,特别是在白人女性中. 需要进一步的研究来了解BrCa启动和生物机制中的种族差异.
科学领域:
- 表观遗传学和癌症研究
- 基因组生物标志物 基因组生物标志物
- 健康差异 在健康上的差异
背景情况:
- 乳腺癌 (BrCa) 不成比例地影响黑人女性,她们比白人女性更早发病,死亡率更高.
- 种族差异在BrCa发病率和结果中的生物学基础在很大程度上是未知的.
- 这项研究调查了表观遗传年龄加速作为BrCa启动的潜在因素及其与种族的关系.
研究的目的:
- 检查整体表观遗传衰老加速与乳腺癌 (BrCa) 发病之间的关联.
- 探索种族在表观遗传年龄加速和BrCa风险之间的关系中扮演的调解角色.
- 确定可能导致BrCa健康差异的生物学机制.
主要方法:
- 使用Illumina EPIC阵列测量了209名女性的血液DNA中的全基因组甲基化.
- 计算了表观遗传年龄加速 (GrimAge),考虑了白细胞分布.
- 一项病例对照研究比较了149名BrCa患者和42名无疾病的对照人群,根据种族进行了分层分析.
主要成果:
- 与对照组相比,乳腺癌 (BrCa) 病例的GrimAge加速 (2.48年,p=0.0056) 和内在的表观遗传年龄加速 (1.72年,p=0.026) 显著增加.
- 每增加一年的GrimAge加速都与14%的BrCa风险增加有关 (OR=1.14).
- 分层分析表明,根据种族可能存在不同的风险,白人女性的几率 (OR=1.17) 比黑人女性 (OR=1.08) 高,尽管由于样本大小的限制,这在统计学上并不显著.
结论:
- 表观遗传年龄加速与乳腺癌 (BrCa) 风险有显著的关联.
- 表观遗传年龄加速与BrCa风险之间的关联可能因种族而异,这表明观察到的健康差异存在潜在的生物机制.
- 需要对更大的样本大小进行进一步的研究,以阐明种族在表观遗传衰老和BrCa发育中的作用.
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