在下下和鼻神经毒素A注射后对口腔运动功能的负面影响,用于发育障碍儿童的唾液注射
Reva M van Eck1,2, Lynn B Orriëns1, Corinne P A Delsing3
1Department of Paediatrics, Division of Paediatric Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Amalia Children's Hospital, Nijmegen, the Netherlands.
Developmental medicine and child neurology
|October 24, 2024
概括
四腺体肉毒神经毒素A (BoNT-A) 注射用于儿科的唾液引起了大多数儿童的轻度,暂时的口腔运动问题. 这些效果与下下注射相当,这表明四腺治疗是一种可行的选择.
科学领域:
- 神经学 神经学
- 儿科 儿科 儿科
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 儿科的唾液流是发育障碍儿童的常见挑战.
- 肉毒神经毒素A (BoNT-A) 注射用于管理过度的唾液流.
- 以前的治疗方法通常涉及下下注射,但疗效可能有所不同.
研究的目的:
- 评估同时注射下下和腺 (四腺) BoNT-A用于儿科唾液的安全性和口腔运动副作用.
- 为了将这些效应与仅注射下下的结果进行比较.
主要方法:
- 125名发育障碍儿童接受四腺BoNT-A注射的回顾性队列研究.
- 评估了口腔运动功能问题的频率,严重程度和持续时间 (吞,饮食,关节).
- 结果与接受下下注治疗的基准队列进行了比较.
主要成果:
- 36.0%的儿童经历了消极的口腔运动效应,主要是饮食困难.
- 大多数影响是轻微的 (62.2%) 并在4周内消失 (53.3%).
- 与下下注射相比,四腺治疗的效果频率和持续时间相似,但中度严重程度的比率更高.
结论:
- 四腺BoNT-A注射用于儿科的唾液流出与常见但通常轻微和短暂的口腔运动副作用有关.
- 结果与下下注射相似,支持四腺治疗作为其他方法失败时的安全替代品.
- 需要进一步的研究来证实在以前未接受过治疗的人群中的概括性.
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