在等待手术干预的患者中,基础细胞癌的自然进展
Mun W Lam1, Helena Wells1, Andrew Zhao2
1Department of Dermatology, Walsall Manor Hospital, Walsall Healthcare NHS Trust, Walsall, UK.
Clinical and experimental dermatology
|October 24, 2024
概括
未经治疗的基底细胞癌 (BCCs) 随着时间的推移而生长,往往导致更复杂的手术. 长时间等待BCC治疗与症状增加和程序困难相关,特别是在头部和部病例中.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 基础细胞癌 (BCCs) 是常见的,缓慢生长的角质细胞瘤.
- 关于未经治疗的BCCs自然史的数据有限.
- 了解BCC进展对于患者管理和手术规划至关重要.
研究的目的:
- 评估未经治疗的基底细胞癌 (BCCs) 的自然进展.
- 评估患者在治疗等待期间的结果,包括症状发展和手术复杂性.
- 确定影响BCC生长和治疗要求的因素.
主要方法:
- 对55名经组织学确认的BCC患者 (70个病变) 的回顾性分析.
- 数据收集的重点是病变生长,症状报告和手术细节.
- 等待时间和临床结果之间的相关性分析.
主要成果:
- 观察到BCC生长率与外科手术等待时间之间存在显著的相关性.
- 20%的患者由于病变进展,需要比最初计划的更复杂的手术.
- 常见的症状包括 (39.4%),皮 (36.4%) 和出血 (30.3%).
- 较长的等待时间与症状增加和手术复杂性增加有关,特别是在头部和部BCC.
结论:
- 在BCC生长和从初始呈现到手术治疗的持续时间之间存在积极的关系.
- 对BCC治疗的延长等待时间可能导致症状恶化,需要更复杂的外科干预.
- 这些发现强调了对基底细胞癌,特别是位于头部和部的基底细胞癌的及时手术治疗的重要性.
相关概念视频
01:30Skin Cancer
3.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.9K
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
02:30Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
01:12Renewal of Skin Epidermal Stem Cells
2.5K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.5K